WASHINGTON (AP) — President Joe Biden expressed hope Monday that the killing of al-Qaida leader Ayman al-Zawahri brings “one more measure of closure” to families of the victims of the Sept. 11, 2001, attacks on the United States.

Biden made the comments as he confirmed that a U.S. drone strike in Afghanistan this weekend killed al-Qaida leader Ayman al-Zawahri.

“He will never again, never again, allow Afghanistan to become a terrorist safe haven because he is gone and we’re going to make sure that nothing else happens,” Biden said in an address from the White House formally announcing the operation.

“This terrorist leader is no more,” Biden said.

He said U.S. intelligence officials tracked al-Zawahri to a home in downtown Kabul where he was hiding out with his family. The president approved the operation last week and it was carried out on Sunday.

THIS IS A BREAKING NEWS UPDATE. AP’s earlier story follows below.

WASHINGTON (AP) — A U.S. drone strike in Afghanistan this weekend killed Ayman al-Zawahri, who took over as al-Qaida leader after Osama bin Laden’s death in a U.S. raid. President Joe Biden was set to announce the killing Monday, delivering a significant counterterrorism win just 11 months after American troops left the country after a two-decade war.

The strike, carried out by the Central Intelligence Agency, was confirmed by five people familiar with the matter who spoke on the condition of anonymity before Biden was set to brief the American people on the details of the operation in a 7: 30 p.m. EDT address to the nation.

Al-Zawahri’s loss eliminates the figure who more than anyone shaped al-Qaida, first as Osama bin Laden’s deputy since 1998, then as his successor. Together, he and bin Laden turned the jihadi movement’s guns to target the United States, carrying out the deadliest attack ever on American soil — the Sept. 11, 2001, suicide hijackings.

Current and former officials began hearing Sunday afternoon that al-Zawahri had been killed in a drone strike, but the administration delayed releasing the information until his death could be confirmed, according to one person.

White House officials declined to confirm al-Zawahri was killed but noted in a statement that the United States conducted a “successful” counterterrorism operation against a significant al-Qaida target, adding that “there were no civilian casualties.”

The house Al-Zawahri was in when he was killed was owned by a top aide to senior Taliban leader Sirajuddin Haqqani, according to a senior intelligence official. The official also added that a CIA ground team and aerial reconnaissance conducted after the drone strike confirmed al-Zawahri’s death. Planning for the operation began six months ago, but intensified in the last two months, the official said.

Over the 20-year war in Afghanistan, the U.S. targeted and splintered al-Qaida, sending leaders into hiding. But America’s exit from Afghanistan last September gave the extremist group the opportunity to rebuild. U.S. military officials, including Gen. Mark Milley, chairman of the Joint Chiefs of Staff, have said that al-Qaida was trying to reconstitute in Afghanistan, where it faced limited threats from the now-ruling Taliban. Military leaders have warned that the group still aspired to attack the U.S.

The 2001 attacks on the World Trade Center and Pentagon made bin Laden America’s Enemy No. 1. But he likely could never have carried it out without his deputy. Bin Laden provided al-Qaida with charisma and money, but al-Zawahri brought tactics and organizational skills needed to forge militants into a network of cells in countries around the world.

Their bond was forged in the late 1980s, when al-Zawahri reportedly treated the Saudi millionaire bin Laden in the caves of Afghanistan as Soviet bombardment shook the mountains around them.

Zawahri, on the FBI’s Most Wanted Terrorist list, had a $25 million bounty on his head for any information that could be used to kill or capture him.

Biden planned to speak from the balcony off the White House Blue Room as he remains in isolation in the residence while he continues to test positive for COVID-19.

Al-Zawhiri and bin Laden plotted the 9/11 attacks that brought many ordinary Americans their first knowledge of al-Qaida.

Photos from the time often showed the glasses-wearing, mild-looking Egyptian doctor sitting by the side of bin Laden. Al-Zawahiri had merged his group of Egyptian militants with bin Laden’s al-Qaida in the 1990s.

“The strong contingent of Egyptians applied organizational know-how, financial expertise, and military experience to wage a violent jihad against leaders whom the fighters considered to be un-Islamic and their patrons, especially the United States,” Steven A. Cook wrote for the Council on Foreign Relations last year.

When the 2001 U.S. invasion of Afghanistan demolished al-Qaida’s safe haven and scattered, killed and captured its members, al-Zawahri ensured al-Qaida’s survival. He rebuilt its leadership in the Afghan-Pakistan border region and installed allies as lieutenants in key positions.

He also reshaped the organization from a centralized planner of terror attacks into the head of a franchise chain. He led the assembling of a network of autonomous branches around the region, including in Iraq, Saudi Arabia, North Africa, Somalia, Yemen and Asia. Over the next decade, al-Qaida inspired or had a direct hand in attacks in all those areas as well as Europe, Pakistan and Turkey, including the 2004 train bombings in Madrid and the 2005 transit bombings in London.

More recently, the al-Qaida affiliate in Yemen proved itself capable of plotting attacks against U.S. soil with an attempted 2009 bombing of an American passenger jet and an attempted package bomb the following year.

But even before bin Laden’s death, al-Zawahri was struggling to maintain al-Qaida’s relevance in a changing Middle East.

He tried with little success to coopt the wave of uprisings that spread across the Arab world starting in 2011, urging Islamic hard-liners to take over in the nations where leaders had fallen. But while Islamists gained prominence in many places, they have stark ideological differences with al-Qaida and reject its agenda and leadership.

Nevertheless, al-Zawahri tried to pose as the Arab Spring’s leader. America “is facing an Islamic nation that is in revolt, having risen from its lethargy to a renaissance of jihad,” he said in a video eulogy to bin Laden, wearing a white robe and turban with an assault rifle leaning on a wall behind him.

Al-Zawahri was also a more divisive figure than his predecessor. Many militants described the soft-spoken bin Laden in adoring and almost spiritual terms.

In contrast, al-Zawahri was notoriously prickly and pedantic. He picked ideological fights with critics within the jihadi camp, wagging his finger scoldingly in his videos. Even some key figures in al-Qaida’s central leadership were put off, calling him overly controlling, secretive and divisive.

Some militants whose association with bin Laden predated al-Zawahri’s always saw him as an arrogant intruder.

“I have never taken orders from al-Zawahri,” Fazul Abdullah Mohammed, one of the network’s top figures in East Africa until his 2011 death, sneered in a memoir posted on line in 2009. “We don’t take orders from anyone but our historical leadership.”

Speaking on Aug. 31, 2021, after the last U.S. troops left Afghanistan, Biden said the U.S. would not let up on its fight against terrorism in that country or elsewhere.

“We will maintain the fight against terrorism in Afghanistan and other countries,” he said. “We just don’t need to fight a ground war to do it.” Previewing the strike that would occur 11 months later, Biden said at the time, “We have what’s called over-the-horizon capabilities, which means we can strike terrorists and targets without American boots on the ground — or very few, if needed.”

There have been rumors of al-Zawahri’s death on and off for several years. But a video surfaced in April of the al-Qaida leader praising a Indian Muslim woman who had defied a ban on wearing a hijab, or headscarf. That footage was the first proof in months that he was still alive.

A statement from Afghanistan’s Taliban government confirmed the airstrike, but did not mention al-Zawahri or any other casualties.

It said it “strongly condemns this attack and calls it a clear violation of international principles and the Doha Agreement,” the 2020 U.S. pact with the Taliban that led to the withdrawal of American forces.

“Such actions are a repetition of the failed experiences of the past 20 years and are against the interests of the United States of America, Afghanistan, and the region,” the statement said.

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Associated Press writers Lolita C. Baldor, Ellen Knickmeyer, Zeke Miller, Aamer Madhani and Darlene Superville in Washington; Rahim Faiez in Islamabad; and Lee Keath in Cairo contributed reporting.